Methods of use
The most common method of use is simply to chew up and swallow the fresh or dried buttons after removing the tufts and sand. This is the way it is almost always done at Indian ceremonies. Most people find the taste of this cactus unbearably bitter. The Indians, however, feel if ones heart is pure, the bitterness will not be tasted. Many have found that by not cringing from the taste, but rather letting ones senses plunge directly to the center of the bitterness, a sort of separation from the offensive flavor is experienced. It is not a difficult trick, but it takes some mental discipline.

People who cannot endure the bitterness of peyote often go to various extremes to get it into the system without having to taste it. One fairly effective method is to drink unsweetened grapefruit juice while chewing it. The acids in the juice somewhat neutralize some of the bitter bases. Another method is to grind the dried buttons in a pepper grinder and pack the pulverized material into capsules which are washed down with warm water. This is an effective method but it can take 20 capsules or more to get a 350mg dose of mescaline.

During the peyote ceremony Indians encourage vomiting rather than restraint if the urge presents itself. Throwing up, they believe, is a purging of both physical and spiritual ills. Most tribes fast for at least a day before taking peyote. This can also help to minimize gastric distress. One should not have eaten for at least 6 hours before taking either mescaline or peyote.
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